Natamycin 5%:
Sterile Ophthalmic suspension. Topical Anti-fungal for ophthalmic use
Composition
Each 1 ml of Natamycin 5%:
Active: micronized Natamycin 50 mg,
Preservative; Benzalkonium chloride 0.02%
Inactive; Polyvinyl alcohol, hydrochloride acid or sodium hydroxide to adjust PH & water for injection.
Indications:
*Natamycln 5% ophthalmic suspension is indicated for the treatment of fungal blepheritis, conjunctivitis, and Keratitis caused by susceptible organisms including Fusarium solani keratitis. As in other forms of suppurative keratitis, initial and sustained therapy of fungal keratitis should be determined by the clinical diagnosis, laboratory diagnosis by smear and culture of corneal scrapings and drug response. Whenever possible the ill vitro activity of Natamycin against the responsible fungus should be determined. The effectiveness of Natamycin as a single agent in fungal endophthalmitis has not been established.
Dosage:
SHAKE Well BEFORE USING.
The preferred initial dosage in fungal keratitis is one drop of Natamycin 5% ophthalmic suspension instilled in the conjunctival sac at hourly or two hourly intervals.
The frequency of application can usually be reduced to one drop 6 to 8 times daily after the first 3 to 4 days. Therapy should generally be continued for 14to 21 days or until there is resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage gradually at 4 to 7 day intervals to assure that the replicating organism has been eliminated. Less frequent initial dosage (4 to 6 daily applications) nay be sufficient in fungal blepheritis and conjunctivitis.
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